Souvik Maiti Lab is situated at CSIR-Institute of Genomics and Integrative Biology. We are interested in unusual nucleic acid structures, their biological roles in non-coding RNA and targeting these by chemically engineered oligonucleotides or small molecules. We use biophysics, molecular biology and zebrafish biology as a tool in our study. We also focus on CRISPR-Cas based gene editing and diagnostics (CRISPRDx FELUDA) for development of diagnostic tests for genetic diseases like Sickle Cell Anemia (SCA) and infectious diseases live COVID-19 along with exploring potential gene editing approaches to correct disease-causing mutations.
Using a combination of biophysical, biochemical and molecular biology methods coupled to computational predictions, we seek to:
Study RNA G quadruplexes and their influence on regulation of gene expression.
Identify small molecule modulators of miRNA function as potential therapeutic leads.
Study the relationship between lncRNA structure and function.
Develop CRSIPR-Cas based diagnostics
Dr. Souvik Maiti is also affiliated with CSIR-National Chemical Laboratory, Pune (as Adjunct Scientist since 2009, Indian Institute of Science Education and Research, Mohali and Indian Institute of Science Education and Research, Kolkata (as Adjunct Professor) since 2020.