We are interested in unusual nucleic acid structures, their biological roles in non-coding RNA and targeting these by chemically engineered oligonucleotides or small molecules. We use biophysics, molecular biology and zebrafish biology as a tool in our study.
Using a combination of biophysical, biochemical and molecular biology methods coupled to computational predictions, we seek to:
- Study RNA G quadruplexes and their influence on regulation of gene expression.
- Identify small molecule modulators of miRNA function as potential therapeutic leads.
- Study the relationship between lncRNA structure and function.